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Anti-rheumatic Drugs: DMARDs : Nonbiologic DMARDs methotrexate , hydroxychloroquine, leflunomide, sulfasalazine : Biologic DMARDs : TNF- inhibitors adalimumab , certolizumab, etanercept , golimumab, infliximab IL-6 receptor antagonists : tocilizumab : Targeted Biologic DMARDs Janus Kinase Inhibitors : tofacitinib, baricitinib, upadacitinib Adjuctive therapies for flare management: NSAIDs, Corticosteroids Anti-inflammatory Drugs : Analgesics : Acetaminophen & Opioids Treatment for methotrexate side effects/toxicity: Folinic acid (Leucovorin) Pathogenesis Figure 3

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For example, IV Vitamin C can achieve blood levels up to 100 times higher, reaching therapeutic concentrations that are otherwise unattainable

In order to investigate the importance of Trp114 hTrxR1 for Trx substrate binding, we mutated Trp114 to Ala